/* ──────────────────────────────────────────────────────────────────────
   DDI CoMed — design system
   Institute of Biomedical Chemistry

   Everything is scoped under .ddi-scope and every class is prefixed
   ddi-, so this file can sit next to Bootstrap 4.4.1 without fighting
   it. Nothing here styles a bare element outside .ddi-scope.

   Fonts come from Google Fonts, which the existing Content-Security-
   Policy in index.php already allows (style-src fonts.googleapis.com,
   font-src fonts.gstatic.com).
   ────────────────────────────────────────────────────────────────────── */

:root {
  /* ink */
  --ddi-ink:        #14171C;
  --ddi-ink-2:      #3C4149;
  --ddi-muted:      #4A5560;
  --ddi-faint:      #666D78;   /* 5.22:1 on white — the lightest text allowed */

  /* surfaces */
  --ddi-ground:     #ECEDE8;
  --ddi-surface:    #FFFFFF;
  --ddi-sunken:     #F6F6F3;
  --ddi-sunken-2:   #FAFAF8;

  /* lines */
  --ddi-rule:       #D8DAD5;
  --ddi-rule-soft:  #E6E7E2;
  --ddi-hair:       #F0F0EC;
  --ddi-field:      #C3C7C0;

  /* accent */
  --ddi-accent:     #1C3F66;
  --ddi-accent-2:   #0F2A47;

  /* the signed difference: blue when Pa > Pi, ochre when Pi > Pa.
     Two hues that differ in lightness too, so the chart survives
     colour blindness and a bad monitor. */
  --ddi-pos:        #2C5C8F;
  --ddi-neg:        #A5693A;
  --ddi-pos-ink:    #143A5E;
  --ddi-neg-ink:    #6B4318;
  --ddi-pos-3:      #C9DAEA;   /* |Pa-Pi| > 0.5  */
  --ddi-pos-2:      #DEE9F2;   /* 0.2 to 0.5     */
  --ddi-pos-1:      #EDF3F8;   /* up to 0.2      */
  --ddi-neg-3:      #EFDDC6;
  --ddi-neg-2:      #F5E9D8;
  --ddi-neg-1:      #FAF4EB;

  /* severity. Each pair is at least 4.5:1. */
  --ddi-major-bg:   #F7E4E8;  --ddi-major-ink:   #7A1828;
  --ddi-mod-bg:     #FAF0DC;  --ddi-mod-ink:     #7A4F09;
  --ddi-minor-bg:   #E6EFF3;  --ddi-minor-ink:   #24566B;

  --ddi-sans:  "IBM Plex Sans", system-ui, -apple-system, sans-serif;
  --ddi-serif: "IBM Plex Serif", Georgia, serif;
  --ddi-mono:  "IBM Plex Mono", ui-monospace, "Cascadia Mono", Consolas, monospace;

  --ddi-max:   1200px;
  --ddi-pad:   32px;
}

/* ─────────── scope ─────────── */

.ddi-scope {
  font-family: var(--ddi-sans);
  font-size: 15px;
  line-height: 1.5;
  color: var(--ddi-ink);
  background: var(--ddi-ground);
  -webkit-font-smoothing: antialiased;
}
.ddi-scope *, .ddi-scope *::before, .ddi-scope *::after { box-sizing: border-box; }
.ddi-scope a { color: var(--ddi-accent); }
.ddi-scope a:hover { color: var(--ddi-accent-2); }
.ddi-scope p { margin: 0; }
.ddi-scope h1, .ddi-scope h2, .ddi-scope h3 { margin: 0; font-weight: 500; letter-spacing: -0.015em; }
.ddi-scope input, .ddi-scope textarea, .ddi-scope select { font: inherit; color: inherit; }
/* A button takes the font but NOT the colour: ".ddi-scope button" is a class
   plus an element (0,1,1) and outweighs ".ddi-btn--primary" (0,1,0), so
   inherit would paint white button text dark. Every button here carries
   .ddi-btn, .ddi-tab or .ddi-subtab, and each sets its own colour. */
.ddi-scope button { font: inherit; }
.ddi-scope ::placeholder { color: var(--ddi-faint); opacity: 1; }

.ddi-wrap { max-width: var(--ddi-max); margin: 0 auto; padding: 0 var(--ddi-pad); }

/* ─────────── masthead ─────────── */

.ddi-head { background: var(--ddi-surface); border-bottom: 1px solid var(--ddi-rule); }
.ddi-head__in {
  max-width: var(--ddi-max); margin: 0 auto; padding: 18px var(--ddi-pad);
  display: flex; flex-wrap: wrap; gap: 24px; align-items: center; justify-content: space-between;
}
.ddi-brand { display: flex; align-items: baseline; gap: 12px; text-decoration: none; color: var(--ddi-ink); }
.ddi-brand__name { font-family: var(--ddi-serif); font-weight: 600; font-size: 26px; }
.ddi-brand__org { font-size: 11px; letter-spacing: 0.1em; text-transform: uppercase; color: var(--ddi-faint); }
.ddi-nav { display: flex; flex-wrap: wrap; gap: 26px; font-size: 14px; }
.ddi-nav a { color: var(--ddi-muted); text-decoration: none; }
.ddi-nav a[aria-current] { color: var(--ddi-ink); font-weight: 500; border-bottom: 2px solid var(--ddi-accent); padding-bottom: 3px; }

/* ─────────── cards, headings ─────────── */

.ddi-card { background: var(--ddi-surface); border: 1px solid var(--ddi-rule); border-radius: 4px; }
.ddi-card--flush-top { border-top: 0; border-radius: 0 0 4px 4px; }
.ddi-card__pad { padding: 24px; }
.ddi-card__head {
  padding: 18px 24px; border-bottom: 1px solid var(--ddi-rule-soft);
  display: flex; flex-wrap: wrap; gap: 20px; align-items: center; justify-content: space-between;
}
.ddi-card__foot { padding: 16px 24px; border-top: 1px solid var(--ddi-rule-soft); font-size: 12px; color: var(--ddi-faint); }

.ddi-h1 { font-family: var(--ddi-serif); font-size: 27px; }
.ddi-h2 { font-family: var(--ddi-serif); font-size: 21px; }
.ddi-h3 { font-family: var(--ddi-serif); font-size: 19px; }
.ddi-hero { font-family: var(--ddi-serif); font-size: 42px; line-height: 1.12; letter-spacing: -0.02em; }
.ddi-lede { font-size: 17px; line-height: 1.55; color: var(--ddi-muted); }
.ddi-sub { font-size: 13px; color: var(--ddi-muted); }
.ddi-note { font-size: 12px; color: var(--ddi-faint); }
.ddi-eyebrow { font-size: 11px; font-weight: 600; letter-spacing: 0.1em; text-transform: uppercase; color: var(--ddi-faint); }
.ddi-id { font-family: var(--ddi-mono); font-size: 12px; color: var(--ddi-faint); }
.ddi-num { font-family: var(--ddi-mono); font-variant-numeric: tabular-nums; }

/* ─────────── buttons and fields ─────────── */

.ddi-scope .ddi-btn {
  display: inline-flex; align-items: center; justify-content: center; gap: 10px;
  min-height: 44px; padding: 0 18px; border: 1px solid var(--ddi-field); border-radius: 3px;
  background: var(--ddi-surface); font-size: 13px; text-decoration: none; color: var(--ddi-ink); cursor: pointer;
}
.ddi-scope .ddi-btn:hover { border-color: var(--ddi-muted); color: var(--ddi-ink); }
.ddi-scope .ddi-btn--primary { border-color: var(--ddi-accent); background: var(--ddi-accent); color: #FFFFFF; font-weight: 500; }
.ddi-scope .ddi-btn--primary:hover { background: var(--ddi-accent-2); border-color: var(--ddi-accent-2); color: #FFFFFF; }
.ddi-scope .ddi-btn--lg { min-height: 48px; padding: 0 30px; font-size: 16px; font-weight: 600; }

.ddi-field { display: flex; flex-direction: column; gap: 7px; }
.ddi-field__label { font-size: 13px; font-weight: 500; }
.ddi-field__hint { font-size: 12px; color: var(--ddi-faint); }
.ddi-input, .ddi-textarea {
  width: 100%; padding: 11px 13px; border: 1px solid var(--ddi-field);
  border-radius: 3px; background: var(--ddi-surface); font-size: 15px;
}
.ddi-textarea { font-family: var(--ddi-mono); font-size: 13px; line-height: 1.5; resize: vertical; }
.ddi-input:focus-visible, .ddi-textarea:focus-visible { outline: 2px solid var(--ddi-accent); outline-offset: 1px; }

.ddi-or { display: flex; align-items: center; gap: 14px; }
.ddi-or::before, .ddi-or::after { content: ""; height: 1px; background: var(--ddi-rule-soft); flex-grow: 1; }
.ddi-or__txt { font-size: 11px; letter-spacing: 0.12em; text-transform: uppercase; color: var(--ddi-faint); }

/* the JSME applet's box, and its placeholder while nothing is mounted */
.ddi-sketch { border: 1px dashed var(--ddi-field); border-radius: 3px; background: var(--ddi-sunken); min-height: 232px; }
.ddi-sketch--empty { display: flex; flex-direction: column; align-items: center; justify-content: center; gap: 7px; text-align: center; padding: 16px; }

/* ─────────── tabs ─────────── */

.ddi-scope .ddi-tabs { border-bottom: 1px solid var(--ddi-rule); display: flex; flex-wrap: wrap; gap: 4px; }
.ddi-scope .ddi-tab {
  padding: 12px 18px; min-height: 44px; display: inline-flex; align-items: center;
  font-size: 14px; color: var(--ddi-muted); text-decoration: none;
  border-bottom: 2px solid transparent; background: none; border-top: 0; border-left: 0; border-right: 0;
}
.ddi-scope .ddi-tab:hover { color: var(--ddi-ink); }
.ddi-scope .ddi-tab.is-active { font-weight: 600; color: var(--ddi-ink); border-bottom-color: var(--ddi-accent); }

/* Sub-tabs: the views inside one group. Only drawn when a group holds
   more than one, because a row with a single pill in it says nothing. */
.ddi-scope .ddi-subtabs { display: flex; flex-wrap: wrap; gap: 6px; padding: 16px 24px 0; }
.ddi-scope .ddi-subtab {
  min-height: 40px; display: inline-flex; align-items: center; padding: 0 14px;
  border: 1px solid var(--ddi-field); border-radius: 3px; background: var(--ddi-surface);
  font-size: 13px; color: var(--ddi-ink); text-decoration: none; cursor: pointer;
}
.ddi-scope .ddi-subtab:hover { border-color: var(--ddi-muted); }
.ddi-scope .ddi-subtab.is-active {
  border-color: var(--ddi-accent); background: var(--ddi-accent);
  color: #FFFFFF; font-weight: 500;
}

/* ─────────── the pair of compounds ─────────── */

.ddi-pair { display: flex; flex-wrap: wrap; gap: 14px; align-items: stretch; }
.ddi-pair__col { flex: 1 1 380px; min-width: 0; }
.ddi-pair__plus { flex: 0 0 34px; display: flex; align-items: center; justify-content: center; font-size: 22px; color: var(--ddi-faint); }
.ddi-mol { display: flex; gap: 16px; align-items: center; padding: 16px 18px; }
.ddi-mol__thumb {
  flex: 0 0 72px; height: 72px; border: 1px solid var(--ddi-rule-soft); border-radius: 3px;
  background: var(--ddi-sunken); display: flex; align-items: center; justify-content: center;
}
.ddi-mol__name { font-size: 17px; font-weight: 600; }
.ddi-mol__meta { font-family: var(--ddi-mono); font-size: 11px; color: var(--ddi-faint); white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }

/* ─────────── tables ─────────── */

.ddi-scroll { overflow-x: auto; }
.ddi-scope .ddi-table { width: 100%; border-collapse: collapse; font-size: 14px; }
.ddi-table th, .ddi-table td { text-align: left; }
.ddi-table thead th {
  padding: 11px 14px; font-size: 11px; font-weight: 600; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--ddi-muted); border-bottom: 1px solid var(--ddi-rule-soft);
  background: var(--ddi-sunken); white-space: nowrap;
}
.ddi-table tbody td, .ddi-table tbody th { padding: 12px 14px; border-bottom: 1px solid var(--ddi-hair); font-weight: 400; }
.ddi-table tbody th { font-weight: 500; }
.ddi-table .ddi-c1 { padding-left: 24px; }
.ddi-table .ddi-cz { padding-right: 24px; }
.ddi-table .ddi-r { text-align: right; font-family: var(--ddi-mono); font-variant-numeric: tabular-nums; white-space: nowrap; }
.ddi-table tbody tr.is-under td { color: var(--ddi-muted); }
.ddi-table__rule td {
  padding: 9px 24px; background: #F2F3EE; border-top: 1px solid var(--ddi-field);
  border-bottom: 1px solid var(--ddi-field); font-size: 11px; letter-spacing: 0.1em;
  text-transform: uppercase; color: var(--ddi-muted);
}
.ddi-pa { color: var(--ddi-ink); }
.ddi-pi { color: var(--ddi-faint); }
.ddi-d--pos { color: var(--ddi-accent); font-weight: 500; }
.ddi-d--neg { color: #7A4F1E; }

/* ─────────── chips ─────────── */

.ddi-chip { display: inline-block; padding: 3px 9px; border-radius: 3px; font-size: 12px; font-weight: 500; white-space: nowrap; }
.ddi-chip--major { background: var(--ddi-major-bg); color: var(--ddi-major-ink); }
.ddi-chip--moderate { background: var(--ddi-mod-bg); color: var(--ddi-mod-ink); }
.ddi-chip--minor { background: var(--ddi-minor-bg); color: var(--ddi-minor-ink); }
.ddi-chip--off { background: #F2F3EE; color: var(--ddi-muted); font-weight: 400; }
.ddi-flag {
  display: inline-block; font-size: 10px; letter-spacing: 0.08em; text-transform: uppercase;
  border: 1px solid var(--ddi-rule); border-radius: 2px; padding: 2px 5px; color: var(--ddi-faint); white-space: nowrap;
}

/* ─────────── the signed difference bar ─────────── */

.ddi-bar { position: relative; height: 12px; background: var(--ddi-sunken); border-radius: 2px; min-width: 120px; }
.ddi-bar__zero { position: absolute; left: 50%; top: -2px; bottom: -2px; width: 1px; background: var(--ddi-field); }
.ddi-bar__fill { position: absolute; top: 1px; bottom: 1px; width: var(--ddi-w, 0%); }
.ddi-bar__fill--pos { left: 50%; background: var(--ddi-pos); border-radius: 0 2px 2px 0; }
.ddi-bar__fill--neg { right: 50%; background: var(--ddi-neg); border-radius: 2px 0 0 2px; }

.ddi-bar--tall { height: 20px; background: var(--ddi-sunken-2); }
.ddi-bar--tall .ddi-bar__zero { top: -3px; bottom: -3px; background: #9AA0A8; }
.ddi-bar--tall .ddi-bar__fill { top: 3px; bottom: 3px; }

.ddi-legend { display: flex; flex-wrap: wrap; gap: 14px; align-items: center; }
.ddi-legend__item { display: inline-flex; align-items: center; gap: 7px; font-size: 12px; color: var(--ddi-muted); }
.ddi-swatch { width: 14px; height: 9px; border-radius: 2px; }

/* the class / activity ladder: label, bar, value */
.ddi-ladder__row { display: flex; gap: 12px; align-items: center; padding: 8px 0; border-top: 1px solid var(--ddi-hair); }
.ddi-ladder__name { flex: 0 0 150px; min-width: 0; font-size: 14px; font-weight: 500; }
.ddi-ladder__bar { flex-grow: 1; min-width: 0; }
.ddi-ladder__val { flex: 0 0 62px; text-align: right; font-family: var(--ddi-mono); font-size: 13px; }
.ddi-ladder__axis {
  display: flex; justify-content: space-between; font-family: var(--ddi-mono);
  font-size: 11px; color: var(--ddi-faint); margin-bottom: 6px;
  padding-left: 162px; padding-right: 66px;
}
.ddi-ink--major { color: var(--ddi-major-ink); }
.ddi-ink--moderate { color: var(--ddi-mod-ink); }
.ddi-ink--minor { color: var(--ddi-minor-ink); }
.ddi-ink--none { color: var(--ddi-muted); }

/* ─────────── the value grid (mechanism × severity, CYP × role) ─────────── */

.ddi-grid { border-collapse: collapse; width: 100%; font-size: 14px; }
.ddi-grid th { text-align: left; font-size: 11px; font-weight: 600; letter-spacing: 0.08em; text-transform: uppercase; color: var(--ddi-muted); }
.ddi-grid thead th { padding: 0 8px 10px; }
.ddi-grid thead th:first-child { padding-left: 0; padding-right: 16px; }
.ddi-grid tbody th { padding: 6px 16px 6px 0; font-size: 14px; font-weight: 500; border-top: 1px solid var(--ddi-hair); }
.ddi-grid tbody td { padding: 6px 4px; border-top: 1px solid var(--ddi-hair); }
.ddi-grid__sep { border-left: 1px solid var(--ddi-rule-soft); }
.ddi-cell {
  display: block; padding: 11px 12px; border-radius: 3px; text-align: center;
  font-family: var(--ddi-mono); font-variant-numeric: tabular-nums; font-size: 14px;
}
.ddi-cell--p3 { background: var(--ddi-pos-3); color: var(--ddi-pos-ink); }
.ddi-cell--p2 { background: var(--ddi-pos-2); color: var(--ddi-pos-ink); }
.ddi-cell--p1 { background: var(--ddi-pos-1); color: var(--ddi-pos-ink); }
.ddi-cell--n3 { background: var(--ddi-neg-3); color: var(--ddi-neg-ink); }
.ddi-cell--n2 { background: var(--ddi-neg-2); color: var(--ddi-neg-ink); }
.ddi-cell--n1 { background: var(--ddi-neg-1); color: var(--ddi-neg-ink); }
.ddi-cell--off { background: var(--ddi-sunken-2); color: var(--ddi-faint); }

/* ─────────── empty and waiting states ─────────── */

.ddi-empty { border: 1px dashed var(--ddi-field); border-radius: 3px; background: var(--ddi-sunken); padding: 22px; text-align: center; }
.ddi-empty__title { font-size: 15px; font-weight: 500; }

/* ─────────── footer ─────────── */

.ddi-foot { background: var(--ddi-surface); border-top: 1px solid var(--ddi-rule); margin-top: 0; }
.ddi-foot__in { max-width: var(--ddi-max); margin: 0 auto; padding: 26px var(--ddi-pad); font-size: 13px; color: var(--ddi-muted); }
.ddi-cite { line-height: 1.65; max-width: 92ch; }

/* ─────────── small layout helpers ─────────── */

.ddi-row { display: flex; flex-wrap: wrap; gap: 20px; align-items: center; justify-content: space-between; }
.ddi-cols { display: flex; flex-wrap: wrap; gap: 24px; align-items: stretch; }
.ddi-cols > * { flex: 1 1 420px; min-width: 0; }
.ddi-stack { display: flex; flex-direction: column; gap: 18px; }
.ddi-cards-4 { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 16px; }
.ddi-mt { margin-top: 22px; }
.ddi-mt-l { margin-top: 44px; }
.ddi-mb { margin-bottom: 22px; }
.ddi-main { padding: 28px 0 64px; }

.ddi-topline { border-top: 3px solid var(--ddi-rule); }
.ddi-topline--major { border-top-color: var(--ddi-major-ink); }
.ddi-topline--moderate { border-top-color: var(--ddi-mod-ink); }
.ddi-topline--minor { border-top-color: var(--ddi-minor-ink); }
.ddi-topline--accent { border-top-color: var(--ddi-accent); }

@media (max-width: 860px) {
  :root { --ddi-pad: 16px; }
  .ddi-cards-4 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .ddi-hero { font-size: 32px; }
  .ddi-ladder__axis { padding-left: 0; padding-right: 0; }
  .ddi-ladder__name { flex-basis: 110px; }
}
@media (max-width: 560px) {
  .ddi-cards-4 { grid-template-columns: minmax(0, 1fr); }
  .ddi-pair__plus { display: none; }
}